DEXTRAN 1 dA?ng A�a�? phA?ng nga��a pha??n va�� do dextran cao phA?n ta��

DEXTRAN 1 dùng để phòng ngừa phản vệ do dextran cao phân tử

Tracuuthuoctay chia sa?� bA�i via??t DEXTRAN 1 dA?ng A�a�? phA?ng nga��a pha??n va�� do dextran cao phA?n ta��lA� gA�? giA? thua��c bao nhiA?u? cha�� A�a��nh, cA?ch sa�� da�?ng, tA?c da�?ng pha�? thua��c DEXTRAN 1.PhA?ng pha??n a��ng pha??n va�� do dextran cao phA?n ta��.

DEXTRAN 1 dA?ng A�a�? phA?ng nga��a pha??n va�� do dextran cao phA?n ta��A�

TA?n chung qua��c ta??: Dextran 1.

MA? ATC: B05A A05.

Loa??i thua��c: Dextran A�??n phA?n ta�� cA? tA?c da�?ng a��c cha?? khA?ng tha�?, dA?ng A�a�? phA?ng nga��a pha??n va�� do dextran cao phA?n ta��.

GiA? thua��c DEXTRAN 1: BA�nh lua?�n cua��i bA�i via??t A�a�? A�?�a�?c thA?ng bA?o giA?

Da??ng thua��c vA� hA�m l?�a�?ng

Dung da��ch A�a�? tiA?m tA�nh ma??ch: 3 g dextran 1 vA� 0,12 g natri clorid/20 ml; pH 4 – 6.

D?�a�?c lA? vA� c?? cha?? tA?c da�?ng

  • Nhia�?u ng?�a�?i ma?�n ca??m va��i dextran, ma?�c dA? ha�? ch?�a bao gia�? A�?�a�?c truya�?n dextran, do A?n cA?c tha��c A?n cha��a cA?c cha??t A�?�a�?ng ra??t gia��ng dextran. Do A�A? cA? nguy c?? ba�� cA?c pha??n a��ng kia�?u ba��nh huya??t thanh, th?�a�?ng bia�?u hia��n lA� pha??n va�� (1 – 2%). Ta??t ca?? cA?c da��ch keo ta�� nhiA?n vA� ta��ng ha�?p dA?ng A�a�? thay tha?? tha�? da��ch A�a�?u cA? tha�? gA?y A�A?p a��ng pha??n va�� hoa?�c kia�?u pha??n va�� typ III: Hoa??t hA?a A�a��c ta�� gA?y pha??n va�� C3a, cA?c enzym trong huya??t t?�??ng vA� tia�?u ca?�u a�Y ma��c A�a�� vA� ta?�n sua??t khA?c nhau. Pha??n a��ng pha??n va�� A�a?�c bia��t na?�ng xa??y ra a�Y ng?�a�?i ba��nh A�A? cA? sa?�n khA?ng tha�? IgG khA?ng dextran. A?A?pa��ng typ III xa??y ra cha?�m h??n A�A?p a��ng typ I (liA?n quan A�a??n IgE – histamin). Do A�A? ca?�n thia??t pha??i a��c cha?? IgG, ba?�ng cA?ch chua?�n ba�� ng?�a�?i ba��nh ba?�ng dextran A�??n phA?n ta�� (dextran 1). Dextran 1 lA� dextran A�??n phA?n ta�� hoa??t A�a��ng nh?� ma��t hapten A�??n A�a��c, ga??n ma��t cA?ch cha�?n la�?c vA�o cA?c khA?ng tha�? khA?ng dextran trong huya??t thanh ca??nh tranh va��i dextran cao phA?n ta��. Na??u A�?�a�?c tiA?m tA�nh ma??ch 1 – 2 phA?t tr?�a��c khi truya�?n dextran cao phA?n ta��, thA� thua��c cA? tA?c da�?ng a��c cha?? hoA�n toA�n cA?c pha��c ha�?p mia��n da��ch. Dextran 1 ga??n vA�o Fab ca��a cA?c IgG, do A�A? a��c cha?? sa�� hA�nh thA�nh cA?c pha��c ha�?p mia��n da��ch vA� ngA?n nga��a pha??n a��ng pha??n va��.
  • TA?c da�?ng nA�y pha�? thua��c vA�o lia�?u. Via��c tiA?m dextran 1 tr?�a��c cho ng?�a�?i ba��nh lA� tuya��t A�a��i ca?�n thia??t vA� va��i lia�?u A�a�� A�a�? trung hA?a khA?ng tha�?.
  • Sau khi truya�?n dextran 48 gia�?, na��ng A�a�� dextran trong huya??t thanh gia??m, cA?n na��ng A�a�� ca��a khA?ng tha�? ta�� do tA?ng lA?n; do va?�y ng?�a�?i ba��nh sa?? cA? nguy c?? ba�� choA?ng pha??n va�� na??u la??i A�?�a�?c truya�?n dextran. Ba�Yi va?�y la??i pha??i tiA?m dextran 1 cho ng?�a�?i ba��nh tr?�a��c ma��i la?�n truya�?n la??i dextran.
  • D?�a�?c A�a��ng ha�?c
  • Na��a A�a�?i tha??i tra�� ca��a dextran 1 lA� 30 phA?t. Dextran 1 hoA�n toA�n A�?�a�?c la�?ca�Y ca?�u tha?�n vA� tha??i theo n?�a��c tia�?u.

Cha�� A�a��nh thua��cA�DEXTRAN 1

  • PhA?ng pha??n a��ng pha??n va�� do dextran cao phA?n ta��.

Cha��ng cha�� A�a��nh

  • KhA?ng cA? cha��ng cha�� A�a��nh va��i dextran 1 khi A�A? cA? cha�� A�a��nh truya�?n dextran cao phA?n ta��.

Tha?�n tra�?ng

  • Na??u khoa??ng tha�?i gian gia�?a tiA?m dextran 1 vA� ba??t A�a?�u truya�?n dextran cao phA?n ta�� lA?u h??n 15 phA?t, ca?�n tiA?m tA�nh ma??ch ma��t lia�?u dextran 1 na�?a.
  • Na??u 48 gia�? sau khi truya�?n dextran cao phA?n ta�� mA� pha??i truya�?n dextran na�?a thA� la??i pha??i tiA?m cho ng?�a�?i ba��nh ma��t lia�?u dextran 1 nh?� tr?�a��c.

TA?c da�?ng khA?ng mong mua��n (ADR)

  • Hia??m ga?�p, ADR < 1/1000
  • ToA�n thA?n: Bua��n nA?n, pha??n a��ng da??ng pha??n va��.
  • Tua?�n hoA�n: Ha?? huya??t A?p, tim cha?�m.
  • Da (ta�� kha�?i vA� khA?ng cA? A? nghA�a lA?m sA�ng): Ha��ng ban, nga��a, nA?ng ba��ng.
  • Pha??n a��ng pha??n va�� do dextran va?�n cA? tha�? xa??y ra ma?�c dA? A�A? da�� phA?ng tr?�a��c ba?�ng dextran 1 (0,0096% sa�� tr?�a�?ng ha�?p). CA?c pha??n a��ng nA�y na?�ng nh?�ng khA?ng gA?y ta�� vong vA� do na��ng A�a�� khA?ng tha�? khA?ng dextran trong huya??t thanh quA? cao.

H?�a��ng da?�n cA?ch xa�� trA� ADR

  • CA?c tA?c da�?ng nA�y th?�a�?ng nha?? vA� khA?ng kA�o dA�i. KhA?ng ca?�n thia??t pha??i A�ia�?u tra�� A�a?�c hia��u.
  • Tuy nhiA?n, pha??i sa?�n sA�ng cA?c ph?�??ng tia��n ca??p ca��u, adrenalin, glucocorticoid, da��ch truya�?n.

Lia�?u l?�a�?ng vA� cA?ch dA?ng

  • Mua��n cA? tA?c da�?ng ta��i A�a, ca?�n tiA?m nhanh 20 ml dung da��ch 15% dextran 1 vA�o tA�nh ma??ch, 1 – 2 phA?t tr?�a��c khi truya�?n dextran.
  • Na??u khoa??ng tha�?i gian gia�?a tiA?m dextran 1 vA� ba??t A�a?�u truya�?n dextran cao phA?n ta�� lA?u h??n 15 phA?t, ca?�n tiA?m tA�nh ma??ch ma��t lia�?u dextran 1 na�?a.
  • Na??u 48 gia�? sau la?�n truya�?n dextran mA� pha??i truya�?n dextran 1 na�?a thA� la??i pha??i tiA?m cho ng?�a�?i ba��nh ma��t lia�?u dextran 1 nh?� tr?�a��c.

T?�??ng ka��

  • CA?c acid vA� kia�?m lA�m cho pH d?�a��i 2 hoa?�c cao h??n 10 cA? tha�? phA? va�? ca??u trA?c dextran 1. Trong mA?i tr?�a�?ng acid, glucose vA� acid sacharinic A�?�a�?c ta??o ra.

A?a�� a��n A�a��nh vA� ba??o qua??n

Ba??o qua??n a�Y n??i cA? nhia��t A�a�� d?�a��i 30oC, khA?ng A�a�? A�A?ng la??nh.

ThA?ng tin qui cha??

Thua��c pha??i A�?�a�?c kA? A�??n vA� bA?n theo A�??n

Ngua��n d?�a�?c th?� qua��c gia

Tham kha??o hA�nh a??nh cA?c dA?ng thua��cA�DEXTRAN 1 dA?ng A�a�? phA?ng nga��a pha??n va�� do dextran cao phA?n ta��

DEXTRAN 1 dA?ng A�a�? phA?ng nga��a pha??n va�� do dextran cao phA?n ta��

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One thought on “DEXTRAN 1 dA?ng A�a�? phA?ng nga��a pha??n va�� do dextran cao phA?n ta��

  1. Huỳnh Kiều says:

    Tracuuthuoctay chia sẻ bài viết DEXTRAN 1 dùng để phòng ngừa phản vệ do dextran cao phân tửlà gì? giá thuốc bao nhiêu? chỉ định, cách sử dụng, tác dụng phụ thuốc DEXTRAN 1.Phòng phản ứng phản vệ do dextran cao phân tử.
    #DEXTRAN 1 , #thuocDEXTRAN 1 #tracuuthuoctay, #yduoc, #nhathuoc

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