HOMATROPIN HYDROBROMID Thua��c nha�? ma??t, cha��ng tia??t acetylcholin

Tracuuthuoctay chia sa?� bA�i via??t HOMATROPIN HYDROBROMID Thua��c nha�? ma??t, cha��ng tia??t acetylcholinA� gA�? giA? thua��c bao nhiA?u? cha�� A�a��nh, cA?ch sa�� da�?ng, tA?c da�?ng pha�? thua��c HOMATROPIN HYDROBROMID.GA?y giA?n A�a��ng ta�� vA� lia��t c?? tha�? mi A�a�? A�o khA?c xa??.A?ia�?u tra�� viA?m ca??p mA�ng ba�� A�A�o.

HOMATROPIN HYDROBROMID Thua��c nha�? ma??t, cha��ng tia??t acetylcholin

TA?n chung qua��c ta??: Homatropine hydrobromide.

MA? ATC: S01F A05.

Loa??i thua��c: Thua��c nha�? ma??t, cha��ng tia??t acetylcholin; thua��c nha�? ma??t, giA?n A�a��ng ta�� vA� lia��t c?? tha�? mi.

GiA? thua��c HOMATROPIN HYDROBROMID: BA�nh lua?�n cua��i bA�i via??t A�a�? A�?�a�?c thA?ng bA?o giA?

Da??ng thua��c vA� hA�m l?�a�?ng

Thua��c nha�? ma??t d?�a��i da??ng mua��i hydrobromid 2% (1 ml, 5 ml); 5% (1 ml, 2 ml, 5 ml, 15 ml) cA? cha��a cha??t ba??o qua??n benzalkonium clorid.

D?�a�?c lA? vA� c?? cha?? tA?c da�?ng

Homatropin lA� ma��t tA?c nhA?n cha��ng muscarin cA? tA?c da�?ng t?�??ng ta�� nh?� atropin. TrA?n ma??t, thua��c gA?y giA?n A�a��ng ta�� vA� lA�m lia��t c?? tha�? mi nhanh h??n vA� nga??n h??n atropin. Do va?�y, nA? hay A�?�a�?c dA?ng va��i ma�?c A�A�ch nA�y h??n atropin. Tuy nhiA?n, tA?c da�?ng gA?y lia��t c?? tha�? mi cA? tha�? khA?ng hoA�n toA�n. Sau khi nha�? thua��c vA�o ma??t, homatropin lA�m co tha??t ma��ng ma??t vA� c?? mi ca��a tha��y tinh tha�? khA?ng A�A?p a��ng va��i kA�ch thA�ch acetylcholin. Do A�A?, thua��c gA?y giA?n A�a��ng ta�� vA� lia��t c?? tha�? mi.

D?�a�?c A�a��ng ha�?c

TA?c da�?ng giA?n A�a��ng ta�� ta��i A�a ca��a homatropin hydrobromid A�a??t A�?�a�?c khoa??ng 10 – 30 phA?t vA� lia��t c?? tha�? mi ta��i A�a khoa??ng 30 – 90 phA?t. TA?c da�?ng giA?n A�a��ng ta�� cA? tha�? kA�o dA�i ta�� 6 gia�? A�a??n 4 ngA�y, vA� lia��t c?? tha�? mi cA? tha�? kA�o dA�i 10 – 48 gia�?.

A?a��c tA�nh toA�n thA?n cA? tha�? xa??y ra sau khi nha�? thua��c homatropin vA�o ma??t.

Cha�� A�a��nh thua��cA�HOMATROPIN HYDROBROMID

GA?y giA?n A�a��ng ta�� vA� lia��t c?? tha�? mi A�a�? A�o khA?c xa??.

A?ia�?u tra�� viA?m ca??p mA�ng ba�� A�A�o.

Cha��ng cha�� A�a��nh

Ma?�n ca??m va��i homatropin.

GlA?cA?m gA?c A�A?ng, xua??t huya??t ca??p.

KhA?ng nA?n dA?ng cho tra?� em d?�a��i 3 thA?ng tua��i vA� cA? tha�? lia��t c?? tha�? mi, gA?y gia??m tha�� la��c.

Tha?�n tra�?ng

Ng?�a�?i ba��nh tA?ng huya??t A?p, cA? ba��nh tim hoa?�c tA?ng nhA?n A?p.

Tha?�n tra�?ng va��i tra?� nha�? vA� ng?�a�?i cao tua��i do ma?�n ca??m cao va��i thua��c, da�� gA?y tA?c da�?ng khA?ng mong mua��n toA�n thA?n.

DA?ng tha?�n tra�?ng trong ba��nh tia??t nia��u ta??c ngha??n, lia��t rua��t, viA?m loA�t A�a??i trA�ng, tA�nh tra??ng tim ma??ch khA?ng a��n A�a��nh trong xua??t huya??t ca??p.

DA?ng homatropin dA�i ngA�y cA? tha�? gA?y kA�ch a��ng ta??i cha��.

CA? tha�? nhA�n ma�? nha??t tha�?i khi nha�? thua��c. Ng?�a�?i ba��nh khA?ng A�?�a�?c lA?i xe hoa?�c A�ia�?u khia�?n mA?y mA?c tra�� phi ma??t va?�n nhA�n rA�.

Tha�?i ka�? mang thai

An toA�n sa�� da�?ng cho ng?�a�?i mang thai ch?�a A�?�a�?c xA?c A�a��nh. VA� homatropin nha�? ma??t cA? tha�? ha??p tha�? toA�n thA?n, nA?n cha�� cA? tha�? dA?ng A�?�a�?c cho pha�? na�? cA? thai sau khi cA?n nha??c la�?i ha??i gia�?a ma?? vA� thai nhi.

Tha�?i ka�? cho con bA?

An toA�n sa�� da�?ng cho pha�? na�? A�ang cho con bA? ch?�a A�?�a�?c xA?c A�a��nh. VA� homatropin nha�? ma??t cA? tha�? A�?�a�?c ha??p tha�? toA�n thA?n, nA?n cha�� dA?ng cho pha�? na�? cho con bA? khi tha?�y thua��c cA?n nha??c tha??y ca?�n thia??t.

TA?c da�?ng khA?ng mong mua��n (ADR)

Ha?�u ha??t cA?c pha??n a��ng cA? ha??i lA� a�Y ma??t, A�a?�c bia��t a�Y ng?�a�?i ba��nh glA?cA?m.

Th?�a�?ng ga?�p, ADR > 1/100

Ma??t: NhA�n ma�?, sa�? A?nh sA?ng, tA?ng nhA?n A?p.

Ta??i cha��: A?au nha��c, kA�ch a��ng ta??i cha��.

HA? ha??p: Sung huya??t pha��i.

A?t ga?�p, 1/1000 < ADR < 1/100

PhA?.Tha?�n kinh trung ?�??ng: Bua��n nga��.

Da: Da��ch ra��, viA?m da da??ng eczema.

Ma??t: ViA?m ka??t ma??c nang.

H?�a��ng da?�n cA?ch xa�� trA� ADR

a?�n ngA?n tay lA?n tA?i la�� trong 1 – 2 phA?t sau khi nha�? thua��c A�a�? gia??m nguy c?? ha??p thu vA� pha??n a��ng toA�n thA?n.

Nga��ng dA?ng thua��c, na??u cA? da??u hia��u ma?�n ca??m hoa?�c kA�ch a��ng dai da??ng hoa?�c tA?ng lA?n.

Lia�?u l?�a�?ng vA� cA?ch dA?ng

Tra?� em:

GA?y giA?n A�a��ng ta�� vA� lia��t c?? tha�? mi A�a�? A�o khA?c xa?? ma??t: Nha�? 1 gia�?t dung da��ch 2% ngay tr?�a��c khi A�o, nha�? thA?m sau khoa??ng 10 phA?t na??u ca?�n. ViA?m mA�ng ba�� A�A�o: Nha�? 1 gia�?t dung da��ch 2%, 2 – 3 la?�n/ngA�y.

Ng?�a�?i la��n:

GiA?n A�a��ng ta�� vA� lia��t c?? tha�? mi A�a�? A�o khA?c xa??: Nha�? 1 – 2 gia�?t dung da��ch 2% hoa?�c 1 gia�?t dung da��ch 5% tr?�a��c khi A�o; nha�? la??i sau 5 – 10 phA?t na??u ca?�n.

ViA?m mA�ng ba�� A�A�o: Nha�? 1 – 2 gia�?t dung da��ch 2% hoa?�c 5%; 2 – 3 la?�n/ngA�y hoa?�c cA?ch 3 – 4 gia�?/la?�n na??u ca?�n.

T?�??ng tA?c thua��c

Khi dA?ng thua��c nha�? ma??t homatropin va��i l?�a�?ng cA? tha�? gA?y ha??p thu toA�n thA?n A�A?ng ka�? thA� cA? tha�? xa??y ra cA?c t?�??ng tA?c nh?� sau: TA?ng tA?c da�?ng cha��ng tia??t acetylcholin khi dA?ng A�a��ng tha�?i va��i cA?c thua��c cha��ng tia??t acetylcholin hoa?�c thua��c cA? hoa??t tA�nh cha��ng tia??t acetylcholin; tA?ng kha?? nA?ng gA?y A�a��c vA�/hoa?�c tA?c da�?ng khA?ng mong mua��n ca��a cA?c thua��c cha��ng nh?�a�?c c??, kali citrat hoa?�c cA?c cha??t ba�� sung kali khi dA?ng cA?ng va��i cA?c thua��c nA�y, vA� lA�m gia??m bA�i tia??t A�?�a�?ng tiA?u hA?a do cha��ng tia??t acetylcholin gA?y ra; khi dA?ng cA?ng va��i cA?c thua��c cA? tA?c da�?ng ha�� tha?�n kinh trung ?�??ng nh?� thua��c cha��ng nA?n, phenothiazin, hoa?�c barbiturat cA? tha�? gA?y ra cA?c tria��u cha��ng nh?� ?�a�?n cong ng?�a�?i, co gia?�t, hA?n mA?, tria��u cha��ng ngoa??i thA?p.

DA?ng A�a��ng tha�?i va��i cA?c thua��c nha�? ma??t cha��ng glA?cA?m vA� tia??t acetylcholin tA?c da�?ng kA�o dA�i nh?� demecarium, echothiophat vA� ioflurophat, homatropin cA? tha�? lA�m gia??m tA?c da�?ng cha��ng glA?cA?m vA� tA?c da�?ng thu ha??p A�a��ng ta�� ca��a cA?c thua��c nA�y; homatropin cA�ng cA? tha�? lA�m gia??m tA?c da�?ng cha��ng A�ia�?u tia??t quy ta�? khi dA?ng cA?c thua��c nA�y A�a�? A�ia�?u tra�� lA?c ma??t.

DA?ng A�a��ng tha�?i va��i carbachol, physostigmin, hoa?�c pilocarpin, homatropin cA? tha�? lA�m gia??m tA?c da�?ng cha��ng glA?cA?m ca��a cA?c thua��c nA�y. TA?c da�?ng giA?n A�a��ng ta�� ca��a homatropin cA�ng ba�� suy gia??m, vA� cA? tha�? sa�� da�?ng tA?c da�?ng A�a��i khA?ng nA�y vA�o via��c A�ia�?u tra�� cA? la�?i.

A?a�� a��n A�a��nh vA� ba??o qua??n

TrA?nh A?nh sA?ng, ba??o qua??n a�Y 15 – 30^oC.

QuA? lia�?u vA� xa�� trA�

Tria��u cha��ng: NhA�n ma�?, bA� A�A?i, nha��p tim nhanh.

A?ia�?u tra��

Na??u ua��ng nha?�m homatropin, ca?�n gA?y nA?n hoa?�c ra��a da?? dA�y va��i dung da��ch

acid tanic 4%.

Na??u cA? tria��u cha��ng toA�n thA?n tiA?m tA�nh ma??ch 0,2 A�a??n 1mg (0,2 mg cho tra?� em) physostigmin d?�a��i da??ng pha loA?ng cA? cha��a 1mg trong 5 ml dung da��ch natri clorid. Dung da��ch pha??i tiA?m cha?�m trong tha�?i gian khA?ng d?�a��i 2 phA?t. Lia�?u cA? tha�? la?�p la??i 5 phA?t ma��t la?�n, cho ta��i ta��ng lia�?u lA� 2 mg cho tra?� em vA� 6mg cho ng?�a�?i la��n trong ta��ng 30 phA?t ma��t.

Physostigmin cha��ng cha�� A�a��nh trong cA?c pha??n a��ng ha?? huya??t A?p.

NA?n theo dA�i A�ia��n tA?m A�a�� trong khi tiA?m physostigmin.

Na??u kA�ch thA�ch, cA? tha�? kia�?m soA?t ba?�ng diazepam hoa?�c bacbiturat.

CA? tha�? A�ia�?u tra�� ha�� tra�? dA?ng oxygen hoa?�c tra�? hA? ha??p; na??u sa��t ca?�n A�a??p n?�a��c mA?t, A�a?�c bia��t A�a��i va��i tra?� em; A�a?�t a��ng thA?ng na??u bA� tia�?u. A?a��i va��i tra?� cA?n bA�, ca?�n pha??i gia�? cho ba�? ma?�t c?? tha�? A�?�a�?c a?�m.

ThA?ng tin qui cha??

Thua��c A�a��c ba??ng A.

Ngua��n d?�a�?c th?� qua��c gia

Tham kha??o hA�nh a??nh cA?c dA?ng thua��cHOMATROPIN HYDROBROMID Thua��c nha�? ma??t, cha��ng tia??t acetylcholinA�

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